Cisplatin mitochondria

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August undefined, 2024

WebJun 30, 2024 · The novel aspect of our work suggested that cisplatin not only induces mitochondrial oxidative damage by attacking DNA and proteins in cancer cells, but also restrain mitochondria self-renewal by inhibiting mitochondrial fission and mitophagy, which lead to damaged mitochondrial accumulation. WebApr 11, 2024 · Introduction. Ovarian cancer (OC) is a lethal gynecological malignancy. Most OC patients benefit from initial treatments with cytoreductive surgery followed by cisplatin (CP)-based chemotherapy 1.However, approximately 70% of OC patients relapse and develop drug-resistance after long-term use of CP 2.Multilayer alterations have been …

Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of …

WebMore functional mitochondria in cisplatin-resistant compared with cisplatin-sensitive cells were associated to enzymatic changes affecting either the electron transport chain (SKOV-3/SKOV-3-R model) or mitochondrial coupling (COV-362/COV-362-R model). WebNational Center for Biotechnology Information list of pareto distributions

A mitochondria-targeted fluorescent probe for cisplatin - Phys.org

WebMay 10, 2024 · Cisplatin is a platinum-based chemotherapeutic that damages genomic DNA leading to cell death. It also damages mitochondrial DNA and induces high levels of mitochondrial reactive oxygen species (mtROS), further sensitising cells to apoptosis. Notably, immature oocytes are particularly vulnerable to cisplatin treatment, a common … WebJul 6, 2016 · Cisplatin (cis diamminedichloroplatinum II, cDDP) is one of the most effective cancer chemotherapeutic agents and is used in the treatment of many types of human malignancies. However, inherent tumour resistance is a major barrier to effective cisplatin therapy. So far, the mechanism of cDDP resistance has not been well defined. WebCisplatin is a widely used antineoplastic agent. However, its major limitation is dose-dependent nephrotoxicity whose precise mechanism is poorly understood. Recent studies have suggested that mitochondrial dysfunction in tubular epithelium contributes to cisplatin-induced nephrotoxicity. im feeling so tired really falling apart song

Mitochondria Participate in Chemoresistance to Cisplatin in …

Cisplatin induced mitochondrial DNA damage in dorsal root …

WebThe additive effects of metformin on cisplatin-induced inhibition of cell proliferation were attenuated under hypoxic conditions, while metformin compromised mitochondrial structure and function. Additional studies are needed to determine the efficacy of this drug combination in vivo. Publication types Research Support, Non-U.S. Gov't MeSH terms WebAug 30, 2024 · Both cisplatin and IFT88-KD caused primary cilia shortening, downregulated mitochondrial oxidative phosphorylation capacity, and had defective fatty acid oxidation and decreased ATP production. Furthermore, IFT88 overexpression enhanced mitochondrial respiration, which partially counteracted cisplatin-induced defective fatty … list of parfocal lensesWebDec 1, 2024 · Cisplatin is a chemotherapeutic drug that suppresses tumour's growth. • Cisplatin’s effectiveness is limited as it causes liver toxicity. • Various natural antioxidants protect against cisplatin-induced hepatotoxicity. • Hepatoprotective mechanisms are antioxidant, anti-inflammatory, and anti-apoptosis. imf efector ov5012

"WebOct 29, 2024 · Cisplatin induced mtDNA leakage into the cytosol-probably through BCL-2-like protein 4 (BAX) pores in the mitochondrial outer membrane-in tubules, with subsequent activation of the cGAS-STING... " - Cisplatin mitochondria

Cisplatin mitochondria

Roles of DNA damage in renal tubular epithelial cells injury

WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine monophosphate … WebKey results: We demonstrated that the prominent mitochondrial fragmentation occurred in experimental models of cisplatin-induced nephrotoxicity, which was coupled to radical oxygen species (ROS) overproduction, deterioration of mitochondrial function, release of apoptogenic factors and the consequent apoptosis.

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WebNov 7, 2024 · Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells. Patients with high-grade serous ovarian … WebJul 7, 2014 · A mitochondria-targeted Pt(IV)-prodrug of cisplatin, Platin-M, was designed by introducing two mitochondria-targeting delocalized lipophilic TPP cations in the axial positions (Fig. 1A). Recently, a Pt(II) …

WebCisplatin is a platinum-based chemotherapeutic agent that induces peripheral neuropathy in 30% of patients. Peripheral neuropathy is the dose limiting side effect, which has no preventative therapy. We have previously shown that cisplatin induces apoptosis in dorsal root ganglion (DRG) sensory neuro … WebFeb 11, 2015 · cisplatin mitochondria imaging Supporting Information Details of chemical synthesis, structural analysis, and biological assays. This material is available free of …

WebApr 23, 2024 · Cisplatin / toxicity Drugs, Chinese Herbal / therapeutic use* Humans Hyperalgesia / chemically induced Hyperalgesia / drug therapy Membrane Potential, Mitochondrial / drug effects Mice Neurotoxicity Syndromes Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism Drugs, Chinese Herbal WebNext, synergistic effect of cisplatin combined with ZD55-MnSOD on ovarian cancer cell SKOV-3 was quantified by combination index (CIN) analysis and expressed as CIN versus fraction affected in Figure 2B. These results showed that the combination of cisplatin and ZD55-MnSOD has an enhanced tumor killing effect.

WebJan 9, 2024 · Cancer Drug 49 Times More Potent than Cisplatin ... business news

WebOct 13, 2024 · Cisplatin also disrupts mitochondrial biogenesis, as indicated by reduced renal expression of the master regulator of mitochondrial biogenesis PPARG coactivator 1 alpha (PPARGC1A, also known... im feeling so lWebNational Center for Biotechnology Information imfeld acrylWebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. Semaglutide is a human glucagon-like peptide-1 receptor agonist (GLP-1R), which is used primarily for the treatment of DM. imf effectWebFunctional validation using SSBP1 knockdown demonstrated that the gene plays an important role in regulating mitochondrial mass. Depletion of SSBP1 increases the sensitivity of tumor cells to cisplatin-induced cell death, but only modestly impacts the ability of tumor cells to proliferate in the absence of the drug. list of parastatals in zimbabwe pdfWebJul 10, 2024 · Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent recurrence of resistance phenomena, it still remains the only therapeutic … imfeld and imfeld property managementWeb2 days ago · Complex 37 and, above all, 38, were the most effective, but the latter led to higher activated Pt content inside the cells (probably because of its greater reduction rate), as well as inside the mitochondria, compared with complex 37 and cisplatin. To explore the mitochondrial effect caused by complexes 37 and 38, the level of mitochondria ... list of parasitic diseases in animalsWebA study in Chinese hamster ovary cells demonstrated that the proportion of adducts of cisplatin on mitochondrial DNA was four to six times higher compared to nuclear DNA by dissociation-enhanced lanthanide fluoroimmunoassay (DELFIA) and immunoelectron microscopy (Olivero et al., 1995; Jamieson and Lippard, 1999). list of parish in louisiana