Ctgf target
WebHerein, we propose that CTGF is a promising cancer therapeutic target that could potentially improve the clinical outcomes of cancer patients. Keywords connective tissue … WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the …
Ctgf target
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WebThe CTGF gene is a transcriptional target of both YAP/TAZ and TGFβ-SMAD signaling pathways (6,7), and aberrant regulation of CTGF expression is strongly associated with pathological conditions, notably cancer and fibrosis (8,9). Chen, C.C. and Lau, L.F. (2009) Int J Biochem Cell Biol 41, 771-83. WebOct 14, 2014 · CTGF is a therapeutic target for metastatic melanoma. Oncogene 33, 1093–1100 (2014). CAS PubMed Google Scholar Neesse, A. et al. CTGF antagonism …
WebFeb 13, 2024 · The downstream target genes of YAP that are of primary interest in this study are Connective Tissue Growth Factor (CTGF) and Cysteine-rich angiogenic protein … WebAug 30, 2024 · CTGF expression is increased in renal fibrosis as well as hepatic fibrosis, and a recent study reported CTGF as a new target in renal fibrosis . In addition, autophagy is essential for the maintenance of kidney homeostasis, structure, and function, and dysregulated autophagy contributes to the pathogenesis of various kidney diseases [ 29 ].
WebTransforming growth factor (TGF)-beta regulates diverse biologic activities including cell growth, cell death or apoptosis, cell differentiation, and extracellular matrix (ECM) synthesis. TGF-beta is believed to be a key mediator of tissue fibrosis as a consequence of ECM accumulation in pathologic … WebSep 11, 2024 · Although the YAP target CTGF was decreased after Ras transformation in MCF10A cells, increased expression is seen after HRas G12V expression in HEK293T cells 25.
Several clinical trials are now ongoing that investigate the therapeutic value of targeting CTGF in fibrosis, diabetic nephropathy, and pancreatic cancer. CTGF (CCN2) has recently been implicated in mood disorders, notably in the postpartum period; these effects may be mediated by its effects on … See more CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). … See more Members of the CCN protein family, including CTGF, are structurally characterized by having four conserved, cysteine-rich domains. These domains are, from N- to C-termini, the insulin-like growth factor binding protein (IGFBP) domain, the von … See more • Ctgf/hcs24 CAESAR • CYR61 (CCN1) See more • Human CTGF genome location and CTGF gene details page in the UCSC Genome Browser. See more Knockout mice with the Ctgf gene disrupted die at birth due to respiratory stress as a result of severe chondrodysplasia. … See more CTGF is associated with wound healing and virtually all fibrotic pathology. It is thought that CTGF can cooperate with TGF-β to induce sustained fibrosis and to exacerbate extracellular matrix production in association other fibrosis-inducing conditions. … See more how long can a cavapoo liveWebOct 5, 2024 · CTGF may be a novel target for BPD therapy in preterm infants. Introduction. Bronchopulmonary dysplasia (BPD) was first described by Northway in 1967 (Northway et al., 1967). Although more than 50 years have passed and the survival rates of premature infants have increased, BPD is still a major complication in these infants (Jain and … how long can a catheter stay inWebSep 6, 2024 · Our previous studies showed that Cx43 was a downstream target protein of CTGF in chondrocytes that regulated cell-to-cell communication [27, 31]. Simultaneously, cementocytes specifically express Cx43 as a gap junction carrier to facilitate intercellular communication . Therefore, we speculated that Cx43 regulated by CTGF was involved in … how long can a cat go missing and come backWebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast … how long can a cat have kittensWebFeb 2, 2014 · Here, we define connective tissue growth factor (CTGF) as a therapeutic target for metastatic melanoma. Clinically, CTGF expression correlates with tumor … how long can a cat stay out in the coldWebApr 11, 2024 · During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological condition caused by virus-induced liver damage. The activation of hepatic stellate cells (HSCs) is a central event in the occurrence and progression of liver fibrosis. Although accumulating evidence has shown that HBV directly stimulates HSC activation, … how long can a cat stay home aloneWebHeadquartered in the greater Washington DC area, CTG Federal has satellite offices throughout the United States. CTG Federal is proud to announce that we are certified as … how long can a cat go constipated