Stub1 chip

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August undefined, 2024

WebDec 21, 2024 · PubMed Abstract: Recent evidence suggests that deletion of STUB1─a pivotal negative regulator of interferon-γ sensing─may potentially clear malignant cells. … WebMar 26, 2024 · CHIP/STUB1 Antibody (C-10) is a mouse monoclonal IgG 1 κ, cited in 16 publications, provided at 200 µg/ml raised against amino acids 73-303 mapping at the C-terminus of CHIP of human origin Anti-CHIP/STUB1 Antibody (C-10) is recommended for detection of CHIP of mouse, rat and human origin by WB, IP, IF and ELISA

Rabbit anti-STUB1/CHIP Antibody - Fortis Life Sciences

WebSTIP1 Homology and U-box Containing Protein 1 (STUB1), also known as Carboxyl Terminus of Hsp70-interacting Protein (CHIP), is a cytoplasmic protein that functions as a U-box Ubiquitin ligase (E3) (1). It is highly expressed in striated muscle and brain and has been observed at lower levels in other organs including the pancreas, lung, liver ... Web2 days ago · The E3 ligases c-Cbl and CHIP are ubiquitination regulators of BCR/ABL. 23 They induce ubiquitin-dependent degradation of mature and immature BCR/ABL, respectively, and efficiently suppress BCR/ABL-dependent leukemic growth. 23 Arsenic sulfide (As 4 S 4) has been reported to upregulate c-Cbl, to enhance the ubiquitination and … season battle pass fortnite

Scilit Article - Chip Protein U-Box Domain Truncation Affects ...

WebFeb 13, 2024 · Background: CHIP, the protein encoded by STUB1, is a central component of cellular protein homeostasis and interacts with several key proteins involved in the … WebSep 24, 2024 · The ubiquitin ligase CHIP (C-terminus of Hsc70-interacting protein) is encoded by STUB1 and promotes ubiquitination of misfolded and damaged proteins. CHIP deficiency has been linked to several diseases, and mutations in the human STUB1 gene are associated with recessive and dominant forms of spinocerebellar ataxias (SCAR16/SCA48). WebAdditionally, several heterozygous mutations in STUB1 have recently been described as a cause of autosomal dominant spinocerebellar ataxia type 48. STUB1 encodes C-terminus of HSC70-interacting protein (CHIP), which functions as an E3 ubiquitin ligase and co-chaperone and has been implicated in several neurodegenerative diseases. publix pharmacy boynton plaza

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Exosomes and STUB1/CHIP cooperate to maintain intracellular

WebSTUB1/CHIP was also immunoprecipitated by rabbit anti-STUB1/CHIP antibody (Product # A301-573A), which recognizes a downstream epitope. For blotting immunoprecipitated … WebJul 27, 2024 · The STUB1 gene (STIP1 Homology And U-Box Containing Protein 1) encodes the CHIP protein containing tetratricopeptide repeats and a U-box that functions as a ubiquitin ligase/cochaperone, involved ... publix pharmacy bradenton commonsWebOct 15, 2024 · CHIP/Stub1 interacts with eIF5A and mediates its degradation. Cellular Signalling, Volume 26, Issue 5, 2014, pp. 1098-1104. Show abstract. eIF5A, containing the unusual amino acid hypusine, is a highly conserved protein essential for the proliferation of eukaryotic cells. Previous studies have demonstrated that the activity of eIF5A was ... season bathing suits

"WebThe carboxy terminus of Hsc70-interacting protein (CHIP, STUB1) is a co-chaperone protein and functional E3 ubiquitin ligase that links the polypeptide binding activity of Hsp70 to … " - Stub1 chip

Stub1 chip

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor …

WebDescription: Homo sapiens STIP1 homology and U-box containing protein 1 (STUB1), transcript variant 2, mRNA. (from RefSeq NM_001293197) RefSeq Summary (NM_001293197): This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and … WebSTUB1 encodes for the protein C-terminus of Hsc70 Interacting Protein (CHIP), an E3 ubiquitin ligase. CHIP is known to regulate proteostasis by recruiting chaperones via a N-terminal… Show more

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WebSTUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down’s syndrome patients. WebApr 4, 2024 · Stub1 maintains proteostasis of master transcription factors in embryonic stem cells. CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation. CHIP protects against MPP(+)/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease.

WebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity and specificity. - Long-term security of supply. - Animal-free production. For more information see here. Our RabMAb ® technology is a patented hybridoma-based technology ... WebSep 9, 2024 · Carboxy-terminus of Hsc70-interacting protein (CHIP), also termed STUB1, is a 35 kDa protein with the dual function of co-chaperone and E3 ubiquitin ligase activity 3,4.

WebRecently, the carboxyl terminus of Hsp70-interacting protein (CHIP), also known as STIP1 homology and U-box containing protein 1 (STUB1), has been identified as a critical regulator of necroptosis . CHIP is a 34.5-kDa cytoplasmic protein comprising the N-terminal tetratricopeptide (TPR) domain, C-terminal U-box domain, and a central coiled-coil ... WebMar 21, 2024 · STUB1 (STIP1 Homology And U-Box Containing Protein 1) is a Protein Coding gene. Diseases associated with STUB1 include Spinocerebellar Ataxia, Autosomal …

WebAug 18, 2024 · Stub1 deletion enhances antigen processing and presentation by sensitizing tumour cells to IFNγ. (a – c) Flow cytometry analysis of cell surface MHC-I on parental, control or independent Stub1...

WebMar 26, 2024 · CHIP/STUB1 Antibody (C-10) is a mouse monoclonal IgG 1 κ, cited in 16 publications, provided at 200 µg/ml. raised against amino acids 73-303 mapping at the C … season bedourie ovenWebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity … season battle pass hypixelWebSTUB1, also named as CHIP, SDCCAG7, UBOX1 and NY-CO-7, is a E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. STUB1/CHIP modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It mediates transfer of non-canonical short ubiquitin chains to HSPA8 … season bdo 2023 publix pharmacy boynton beach flWebSTUB1/CHIP is 303 amino acids (aa) in length with a predicted molecular weight of 34.8 kDa. Human STUB1/CHIP shares 97% aa sequence identity with the mouse ortholog but only 67% sequence identity with the rat … publix pharmacy bradentonWebBrowse the : « Home » page. Food Basics, always more for less! season beefWebApr 4, 2024 · STUB1 is an intracellular checkpoint for interferon gamma sensing. STUB1-SMYD2 Axis Regulates Drug Resistance in Glioma cells. Regulation of STUB1 expression … season bat price